Wang Lab Publications
Latest Findings
Stem Cell therapy Improves Human Islet Graft Survival in Mice via Regulation of Macrophages.
Gou W, Hua W, Swaby L, Cui W, Green E, Morgan K, Strange C, Wang H. Diabetes. 2022 Sep 6:db220117. doi: 10.2337/db22-0117. Online ahead of print.
Latest Findings
A Novel Cellular Therapy to Treat Pancreatic Pain in Experimental Chronic Pancreatitis Using Human Alpha-1 Antitrypsin Overexpressing Mesenchymal Stromal Cells
2021 November
Chow RP, Nguyen K, Gou W, Green E, Morgan K, Lancaster W, Helke K, Strange C, Wang H. Biomedicines. 2021 Nov 16;9(11). PubMed PMID: 34829924.
Proteomic Analysis of Exosomes Secreted from Human Alpha-1 Antitrypsin Overexpressing Mesenchymal Stromal Cells
2022 January
Wei, Hua, Green E, Ball L, Fan H, Lee J, Strange C, Wang H. Biology. 2022, 11(1), 9; https://doi.org/10.3390/biology11010009
Featured Publication
Islet Harvest in Carbon Monoxide-Saturated Medium for Chronic Pancreatitis Patients Undergoing Islet Autotransplantation
2019 December
Wang H, Gou W, Strange C, Wang J, Nietert PJ, Cloud C, Owzarski S, Shuford B, Duke T, Luttrell L, Lesher A, Papas KK, Herold KC, Clark P, Usmani-Brown S, Kitzmann J, Crosson C, Adams DB, Morgan KA.
​Cell Transplant. 2019 Dec;28(1_suppl):25S-36S.
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Wang H, Gou W, Adams D, Morgan K, Nietert PJ, Hirsch J, Strange C. 839-P: Alpha-1 Antitrypsin Augmentation Therapy in Chronic Pancreatitis Patients Undergoing Total Pancreatectomy and Islet Autotransplantation. Diabetes. 2023 June 20; 72(Supplement_1). https://doi.0rg/10.2337/db23-839-P
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Shoeibi S, Green E, Wei H, Gou W, Strange C, Wang H. Immortalized Mesenchymal Stromal Cells Overexpressing Alpha-1 Antitrypsin Protect Acinar Cells from Apoptotic and Ferroptotic Cell Death. Res Sq [Preprint]. 2023 Aug 9:rs.3.rs-2961444. doi: 10.21203/rs.3.rs-2961444/v1. PMID: 37609340; PMCID: PMC10441457.
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Wei H, Gou W, Lofty A, Green E, Strange C, Wang H. Mesenchymal Stem/Stromal Cells: ALPHA-1 ANTITRYPSIN OVEREXPRESSING MESENCHYMAL STROMAL CELLS PREVENTS ONSET OF TYPE 1 DIABETES. Cytotherapy. 2023 May; 25(6):S98. https://doi.org/10.1016/S1465-3249(23)00310-9
Gou W, Wei H, Swaby L, Green E, Wang H. Deletion of Spinophilin Promotes White Adipocyte Browning. Pharmaceuticals. 2023 Jan; 16(1):91. https://doi.org/10.3390/ph16010091
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Chow RP, Nguyen K, Gou W, Green E, Morgan K, Lancaster W, Helke K, Strange C, Wang H. A Novel Cellular Therapy to Treat Pancreatic Pain in Experimental Chronic Pancreatitis Using Human Alpha-1 Antitrypsin Overexpressing Mesenchymal Stromal Cells. Biomedicines. 2021 Nov 16;9(11). PubMed PMID: 34829924.
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Sakihama H, Lee GR, Chin BY, Csizmadia E, Gallo D, Qi Y, Gagliani N, Wang H, Bach FH, Otterbein LE. Carbon Monoxide Suppresses Neointima Formation in Transplant Arteriosclerosis by Inhibiting Vascular Progenitor Cell Differentiation. Arterioscler Thromb Vasc Biol. 2021 Jun;41(6):1915-1927. PubMed PMID: 33853347; PubMed Central PMCID: PMC8159904.
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Gou W, Cui W, Cui Y, Wang H. Minimizing Post-Infusion Portal Vein Bleeding during Intrahepatic Islet Transplantation in Mice. J Vis Exp. 2021 May 10;(171). PubMed PMID: 34028442.
Gou W, Wang J, Song L, Kim DS, Cui W, Strange C, Wang H. Alpha-1 antitrypsin suppresses macrophage activation and promotes islet graft survival after intrahepatic islet transplantation. Am J Transplant. 2021 May;21(5):1713-1724. PubMed PMID: 33047509; PubMed Central PMCID: PMC8082666.
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Gou W, Swaby L, Wolfe AM, Lancaster WP, Morgan KA, Wang H. A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion. J Vis Exp. 2021 Feb 28;(168). doi: 10.3791/62080. PubMed PMID: 33720138; PubMed Central PMCID: PMC8601589.
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Song L, Gou W, Wang J, Wei H, Lee J, Strange C, Wang H. Overexpression of alpha-1 antitrypsin in mesenchymal stromal cells improves their intrinsic biological properties and therapeutic effects in nonobese diabetic mice. Stem Cells Transl Med. 2021 Feb;10(2):320-331. PubMed PMID: 32945622; PubMed Central PMCID: PMC7848369.
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Zhang Y, Song L, Dong H, Kim DS, Sun Z, Boger H, Wang Q, Wang H. Spinophilin-deficient mice are protected from diet-induced obesity and insulin resistance. Am J Physiol Endocrinol Metab. 2020 Aug 1;319(2):E354-E362. doi: 10.1152/ajpendo.00114.2020. Epub 2020 Jun 30. PubMed PMID: 32603260; PubMed Central PMCID: PMC7473908.
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Song L, Kim DS, Gou W, Wang J, Wang P, Wei Z, Liu B, Li Z, Gou K, Wang H. GRP94 regulates M1 macrophage polarization and insulin resistance. Am J Physiol Endocrinol Metab. 2020 Jun 1;318(6):E1004-E1013. doi: 10.1152/ajpendo.00542.2019. Epub 2020 Mar 24. PubMed PMID: 32208002; PubMed Central PMCID: PMC7311672.
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An R, Zhang Y, Qiao Y, Song L, Wang H, Dong X. Adipose stem cells isolated from diabetic mice improve cutaneous wound healing in streptozotocin-induced diabetic mice. Stem Cell Res Ther. 2020 Mar 17;11(1):120. doi: 10.1186/s13287-020-01621-x. PubMed PMID: 32183899; PubMed Central PMCID: PMC7079496.
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Wang H, Gou W, Strange C, Wang J, Nietert PJ, Cloud C, Owzarski S, Shuford B, Duke T, Luttrell L, Lesher A, Papas KK, Herold KC, Clark P, Usmani-Brown S, Kitzmann J, Crosson C, Adams DB, Morgan KA. Islet Harvest in Carbon Monoxide-Saturated Medium for Chronic Pancreatitis Patients Undergoing Islet Autotransplantation. Cell Transplant. 2019 Dec;28(1_suppl):25S-36S. PubMed PMID: 31885286; PubMed Central PMCID: PMC7016471.
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Wang J, Gou W, Kim DS, Strange C, Wang H. Clathrin-mediated Endocytosis of Alpha-1 Antitrypsin is Essential for its Protective Function in Islet Cell Survival. Theranostics. 2019;9(13):3940-3951. doi: 10.7150/thno.31647. eCollection 2019. PubMed PMID: 31281523; PubMed Central PMCID: PMC6587339.
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Wang J, Zhang Y, Cloud C, Duke T, Owczarski S, Mehrotra S, Adams DB, Morgan K, Gilkeson G, Wang H. Mesenchymal Stem Cells from Chronic Pancreatitis Patients Show Comparable Potency Compared to Cells from Healthy Donors. Stem Cells Transl Med. 2019 May;8(5):418-429. doi: 10.1002/sctm.18-0093. Epub 2019 Jan 24. PubMed PMID: 30680957; PubMed Central PMCID: PMC6477001.
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Zhang Y, Parajuli KR, Fava GE, Gupta R, Xu W, Nguyen LU, Zakaria AF, Fonseca VA, Wang H, Mauvais-Jarvis F, Sloop KW, Wu H. GLP-1 Receptor in Pancreatic α-Cells Regulates Glucagon Secretion in a Glucose-Dependent Bidirectional Manner. Diabetes. 2019 Jan;68(1):34-44. doi: 10.2337/db18-0317. Epub 2018 Nov 2. PubMed PMID: 30389749; PubMed Central PMCID: PMC6302540.
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Wang M, Song L, Strange C, Dong X, Wang H. Therapeutic Effects of Adipose Stem Cells from Diabetic Mice for the Treatment of Type 2 Diabetes. Mol Ther. 2018 Aug 1;26(8):1921-1930. doi: 10.1016/j.ymthe.2018.06.013. Epub 2018 Jun 19. PubMed PMID: 30005867; PubMed Central PMCID: PMC6094391.
Kim DS, Song L, Wang J, Wu H, Gou W, Cui W, Kim JS, Wang H. Carbon Monoxide Inhibits Islet Apoptosis via Induction of Autophagy. Antioxid Redox Signal. 2018 May 10;28(14):1309-1322. doi: 10.1089/ars.2016.6979. Epub 2017 Nov 27. PubMed PMID: 28826228; PubMed Central PMCID: PMC5905947.
Morgan KA, Lancaster WP, Owczarski SM, Wang H, Borckardt J, Adams DB. Patient Selection for Total Pancreatectomy with Islet Autotransplantation in the Surgical Management of Chronic Pancreatitis. J Am Coll Surg. 2018 Apr;226(4):446-451. doi: 10.1016/j.jamcollsurg.2017.12.018. Epub 2017 Dec 28. PubMed PMID: 29289751.
Year 2017
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Kim DS, Song L, Wang J, Wu H, Gu G, Sugi Y, Li Z, Wang H. GRP94 Is an Essential Regulator of Pancreatic β-Cell Development, Mass, and Function in Male Mice. Endocrinology. 2018 Feb 1;159(2):1062-1073. doi: 10.1210/en.2017-00685. PubMed PMID: 29272356; PubMed Central PMCID: PMC5793778.
Wang H, Strange C, Nietert PJ, Wang J, Turnbull TL, Cloud C, Owczarski S, Shuford B, Duke T, Gilkeson G, Luttrell L, Hermayer K, Fernandes J, Adams DB, Morgan KA. Autologous Mesenchymal Stem Cell and Islet Cotransplantation: Safety and Efficacy. Stem Cells Transl Med. 2018 Jan;7(1):11-19. doi: 10.1002/sctm.17-0139. Epub 2017 Nov 21. PubMed PMID: 29159905; PubMed Central PMCID: PMC5746145.
Sun Z, Gou W, Kim DS, Dong X, Strange C, Tan Y, Adams DB, Wang H. Adipose Stem Cell Therapy Mitigates Chronic Pancreatitis via Differentiation into Acinar-like Cells in Mice. Mol Ther. 2017 Nov 1;25(11):2490-2501. doi: 10.1016/j.ymthe.2017.06.016. Epub 2017 Aug 4. PubMed PMID: 28784560; PubMed Central PMCID: PMC5675167.
Song L, Sun Z, Kim DS, Gou W, Strange C, Dong H, Cui W, Gilkeson G, Morgan KA, Adams DB, Wang H. Adipose stem cells from chronic pancreatitis patients improve mouse and human islet survival and function. Stem Cell Res Ther. 2017 Aug 30;8(1):192. doi: 10.1186/s13287-017-0627-x. PubMed PMID: 28854965; PubMed Central PMCID: PMC5577777.
Wang J, Wang H. Oxidative Stress in Pancreatic Beta Cell Regeneration. Oxid Med Cell Longev. 2017;2017:1930261. doi: 10.1155/2017/1930261. Epub 2017 Aug 3. Review. PubMed PMID: 28845211; PubMed Central PMCID: PMC5560096.
Dong H, Zhang Y, Wang J, Kim DS, Wu H, Sjögren B, Gao W, Luttrell L, Wang H. Regulator of G protein signaling 2 is a key regulator of pancreatic β-cell mass and function. Cell Death Dis. 2017 May 25;8(5):e2821. doi: 10.1038/cddis.2016.216. PubMed PMID: 28542139; PubMed Central PMCID: PMC5520679.
Wang J, Sun Z, Gou W, Adams DB, Cui W, Morgan KA, Strange C, Wang H. α-1 Antitrypsin Enhances Islet Engraftment by Suppression of Instant Blood-Mediated Inflammatory Reaction. Diabetes. 2017 Apr;66(4):970-980. doi: 10.2337/db16-1036. Epub 2017 Jan 9. PubMed PMID: 28069642; PubMed Central PMCID: PMC5360304.
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Tan Y, Richards D, Coyle RC, Yao J, Xu R, Gou W, Wang H, Menick DR, Tian B, Mei Y. Cell number per spheroid and electrical conductivity of nanowires influence the function of silicon nanowired human cardiac spheroids. Acta Biomater. 2017 Mar 15;51:495-504. doi: 10.1016/j.actbio.2017.01.029. Epub 2017 Jan 10. PubMed PMID: 28087483; PubMed Central PMCID: PMC5346043.
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Gou W, Hua W, Swaby L, Cui W, Green E, Morgan K, Strange C, Wang H. Stem Cell therapy Improves Human Islet Graft Survival in Mice via Regulation of Macrophages. Diabetes. 2022 Sep 6:db220117. doi: 10.2337/db22-0117.
Wei H, Green E, Ball L, Fan H, Lee J, Strange C, Wang H. Proteomic Analysis of Exosomes Secreted from Human Alpha-1 Antitrypsin Overexpressing Mesenchymal Stromal Cells. Biology. 2022; 11(1):9. https://doi.org/10.3390/biology11010009
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